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Title   Vinorelbine Tartrate 투여 시간에 따른 Venous Irritation 의 발생에 관한 연구 ( Venous Irritation Incidence Associated with Vinorelbine Tartrate Injection Time )
Publicationinfo   2000 Jan; 032(04): 699-705.
Key_word   Vinorelbine tartrate, Venous irritation, Infusion time
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Abstract   Purpose: This study was to determine the incidence and severity of venous irriation in patients receiving vinorelbine tartrate (Navelbine) in combination chemotherapy. Material and Methods: Twenty four patients histologically confirmed non-small cell lung cancer were enrolled in this study who receiving vinorelbine in combination chemotherapy through a peripheral vein from Oct. 1997 to Mar. 1999 with retrospective study design method. One group was 6-10 minutes infusion rate, the other was 10-20 minutes infusion rate with the same free-flow intravenous infusion. Results: A total of 126 infusions were observed in this study. Sixty-two infusions were administered at the 6 10 minutes, and 64 infusions were administered at the 10-20 minutes. The incidence of any venous irritation was 3.2% (2/62) in the group that received the infusion in 6-10 minutes and 10.9% (7/64) in 10-20 minutes (p=0.164), so we could not acquire any statistical significance. However the incidence of severe venous irritation (grade 3, 4) was 0% (0/62) in 6-10 minutes infusion group and 9.4% (6/64) in 10-20 minutes infusion group. There was a significant difference between two groups (p=0.028) Conclusion: Our results suggest that venous irritation associated with vinorelbine tartrate infusion can be reduced by shorter duration of administration and vinorelbine tartrate might be recom- mended to administer at 6-10 minutes infusion in clinical practice.
저 자   서재홍(Jae Hong Seo),최철원(Chul Won Choi),김병수(Byung Soo Kim),신상원(Sang Won Shin),김열홍(Yeul Hong Kim),김준석(Jun Suk Kim),허경욱(Kyung Wook Hur),정진의(Jin Eui Jung)